Targeting fungal lipid synthesis for antifungal drug development and potentiation of contemporary antifungals

Abstract Two of the three most commonly used classes of antifungal drugs target the fungal membrane through perturbation of sterol biosynthesis or function. In addition to these triazole and polyene antifungals, recent research is identifying new antifungal molecules that perturb lipid biosynthesis...

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Bibliographic Details
Main Authors: Cecilia Gutierrez-Perez, Robert A. Cramer
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:npj Antimicrobials and Resistance
Online Access:https://doi.org/10.1038/s44259-025-00093-4
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