Exploring the nucleus accumbens circuit and oxytocin therapy in a Sapap3 knockout mouse model of trichotillomania

Exploring the nucleus accumbens circuit and oxytocin therapy in a Sapap3 knockout mouse model of trichotillomania

Abstract Trichotillomania (TTM), an understudied psychiatric disorder, was investigated using Sapap3 knockout (KO) mice to elucidate nucleus accumbens (NAc) circuit dysfunction and oxytocin’s therapeutic potential. Under aversive conditions, KO mice exhibited TTM-like behavioral phenotypes compared...

Full description

Saved in:
Bibliographic Details
Main Authors: Yuan Wang, Jingjing Yu, Rui Ma, Yundong Chen, Shihao Lu, Jianqun Fang
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Scientific Reports
Subjects:
Sapap3
Trichotillomania (TTM)
Nucleus accumbens (NAc)
Oxytocin treatment
Dopamine signaling pathway
Online Access:https://doi.org/10.1038/s41598-025-14076-y
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41598-025-14076-y

Similar Items