The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination.

The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination.

Growth factors of the gp130 family promote oligodendrocyte differentiation, and viability, and myelination, but their mechanisms of action are incompletely understood. Here, we show that these effects are coordinated, in part, by the transcriptional activator Krüppel-like factor-6 (Klf6). Klf6 is ra...

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Main Authors: Benjamin M Laitman, Linnéa Asp, John N Mariani, Jingya Zhang, Jia Liu, Setsu Sawai, Candice Chapouly, Sam Horng, Elisabeth G Kramer, Nesanet Mitiku, Hannah Loo, Natalie Burlant, Xiomara Pedre, Yuko Hara, German Nudelman, Elena Zaslavsky, Young-Min Lee, David A Braun, Q Richard Lu, Goutham Narla, Cedric S Raine, Scott L Friedman, Patrizia Casaccia, Gareth R John
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-05-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1002467&type=printable
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1002467&type=printable

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