Sialylated IgG expressed in triple-negative breast cancer cells promotes cancer progression by promoting glycolysis

Sialylated IgG expressed in triple-negative breast cancer cells promotes cancer progression by promoting glycolysis

Abstract Background Triple-negative breast cancer (TNBC) is among the most aggressive and lethal subtypes of breast cancer. To date, there are no effective targeted treatment targets. Sialylated IgG (SIA-IgG), with unique sialylated modifications for N-glycosylation at site 162 of the heavy chain of...

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Bibliographic Details
Main Authors: Chenyang Hu, Shenghua Zhang, Fugang Duan, Xinmei Huang, Jing Huang, Zhu Zhu, Xiaoning Mo, Weiyan Xu, Lina Wu, Zhimin Fan, Xiaoyan Qiu
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Breast Cancer Research
Subjects:
Triple-negative breast cancer
Sialylated IgG / SIA-IgG
Glycolysis
Metabolic reprogramming
Targeted therapy
Online Access:https://doi.org/10.1186/s13058-025-02052-3
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https://doi.org/10.1186/s13058-025-02052-3

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