Non-inferiority of sodium zirconium cyclosilicate versus potassium-restricted diet in achieving normokalaemia in patients with type 2 diabetes mellitus: protocol for a multicentre, open-label, randomised controlled, two-arm clinical trial (SILVERSTAR study)

Non-inferiority of sodium zirconium cyclosilicate versus potassium-restricted diet in achieving normokalaemia in patients with type 2 diabetes mellitus: protocol for a multicentre, open-label, randomised controlled, two-arm clinical trial (SILVERSTAR study)

Background To effectively manage the progression of diabetic kidney disease, it is essential to address the associated hyperkalaemia while concurrently using renin-angiotensin-aldosterone system inhibitors and mineralocorticoid receptor antagonists. In this study, we aim to evaluate the effects of a...

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Main Authors: Masahiro Yamazaki, Michiaki Fukui, Masahide Hamaguchi, Yoshitaka Hashimoto, Toru Tanaka, Noriyuki Kitagawa, Shinichi Mogami, Akinori Kogure, Michiyo Ishii, Naoto Nakamura, Hiroshi Okada, Takuya Fukuda, Takeshi Tsutsumi, Takafumi Osaka, Junya Hironaka, Genki Kobayashi, Muhei Tanaka, Kazuteru Mitsuhashi, Takashi Yoshimura, Miho Yano, Akane Kitamura, Akio Kishi, Ryo Bamba, Eiko Sato
Format: Article
Language:English
Published: BMJ Publishing Group 2025-03-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/15/3/e089564.full
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