Hidden origami in Trypanosoma cruzi nuclei highlights its non-random 3D genomic organization

Hidden origami in Trypanosoma cruzi nuclei highlights its non-random 3D genomic organization

ABSTRACT The protozoan Trypanosoma cruzi is the causative agent of Chagas disease and is known for its polycistronic transcription, with about 50% of its genome consisting of repetitive sequences, including coding (primarily multigenic families) and non-coding regions (such as ribosomal DNA, spliced...

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Bibliographic Details
Main Authors: Natália Karla Bellini, Pedro Leonardo Carvalho de Lima, David da Silva Pires, Julia Pinheiro Chagas da Cunha
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mBio
Subjects:
Trypanosoma cruzi
Hi-C
nuclear architecture
CF unities
TAD boundaries
epigenetic
Online Access:https://journals.asm.org/doi/10.1128/mbio.03861-24
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https://journals.asm.org/doi/10.1128/mbio.03861-24

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