Hepatocellular carcinoma escapes immune surveillance through deceiving thymus into recalling peripheral activated CD8+ T cells

Hepatocellular carcinoma escapes immune surveillance through deceiving thymus into recalling peripheral activated CD8+ T cells

The role of thymic epithelial cells (TECs) in eliminating self-reactive T cells through the presentation of self-antigens is well-established. However, it remains unclear whether TECs can eliminate tumor-reactive CD8+ T cells by presenting tumor antigens. In this study, we observed that CD73+ Granzy...

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Bibliographic Details
Main Authors: Qiaoting Hu, Xuefeng Wang, Yundan You, Jun Liu, Bin Lan, Fangfang Chen, Hong Wen, Haili Cheng, Weibin Zhuo, Ting Xu, Jingxian Zheng, Yuchuan Jiang, Xiaojie Wang, Jing Lin, Zengqing Guo, Sha Huang, Gang Chen, Yu Chen, Jingfeng Liu
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
HCC
CD8+ T cells
CCR7
Thymic epithelial cells
Activation-induced cell death (AICD)
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000909
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