Imaging the impact of sex and age on OATP function in humans: Consequences for whole-body pharmacokinetics and liver exposure

Imaging the impact of sex and age on OATP function in humans: Consequences for whole-body pharmacokinetics and liver exposure

Organic anion-transporting polypeptides (OATP) transporter function, which mediates many drugs' liver uptake, was investigated as a molecular determinant of pharmacokinetic variability. Whole-body PET imaging using 11C-glyburide, a metabolically stable OATP probe, was performed in 16 healthy hu...

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Bibliographic Details
Main Authors: Solène Marie, Anne-Lise Lecoq, Louise Breuil, Fabien Caillé, Vincent Lebon, Claude Comtat, Sébastien Goutal, Laurent Becquemont, Michel Bottlaender, Céline Verstuyft, Nicolas Tournier
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Liver exposure
Imaging
Drug transporter
Drug–drug interaction
Drug-induced liver injury
Pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525001698
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