Neisseria meningitidis regulates P-glycoprotein transporter activity in brain endothelial cells via sphingosine 1–phosphate receptor 1

Neisseria meningitidis regulates P-glycoprotein transporter activity in brain endothelial cells via sphingosine 1–phosphate receptor 1

Abstract Background The brain endothelial cells (BECs) are essential for protecting the central nervous system (CNS) from xenobiotics and pathogens, including Neisseria meningitidis, while maintaining CNS homeostasis through tight junction (TJ) proteins and specialized transporters. Among these, mul...

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Bibliographic Details
Main Authors: Fatemeh Nosratabadi, Leo M. Endres, Fabian Schumacher, Heike Claus, Burkhard Kleuser, Brandon J. Kim, Alexandra Schubert-Unkmeir
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Fluids and Barriers of the CNS
Subjects:
Neisseria meningitidis
Brain endothelial cells
Efflux transporter
P-glycoprotein
Breast cancer resistance protein
Sphingosine 1-phosphate receptor 1
Online Access:https://doi.org/10.1186/s12987-025-00687-0
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https://doi.org/10.1186/s12987-025-00687-0

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