Network Pharmacology Reveals Polyphyllin II as One Hit of Nano Chinese Medicine Monomers against Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma (NPC) is a malignant tumor in southern China, and nano Traditional Chinese Medicine (TCM) represents great potential to cancer therapy. To predict the potential targets and mechanism of polyphyllin II against NPC and explore its possibility for the future nano-pharmaceutics...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Bioinorganic Chemistry and Applications |
| Online Access: | http://dx.doi.org/10.1155/2021/9959634 |
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| author | Meng-Zhe Yang Bei-Bei Zhang Jian-Chun Huang Xian-Yu Bai Zhen-Qiang Liang Xiang Yi Ning Xu Yuan-Jiao Huang Ai-Jun Jiao |
| author_facet | Meng-Zhe Yang Bei-Bei Zhang Jian-Chun Huang Xian-Yu Bai Zhen-Qiang Liang Xiang Yi Ning Xu Yuan-Jiao Huang Ai-Jun Jiao |
| author_sort | Meng-Zhe Yang |
| collection | DOAJ |
| description | Nasopharyngeal carcinoma (NPC) is a malignant tumor in southern China, and nano Traditional Chinese Medicine (TCM) represents great potential to cancer therapy. To predict the potential targets and mechanism of polyphyllin II against NPC and explore its possibility for the future nano-pharmaceutics of Chinese medicine monomers, network pharmacology was included in the present study. Totally, ninety-four common potential targets for NPC and polyphyllin II were discovered. Gene Ontology (GO) function enrichment analysis showed that biological processes and functions mainly concentrated on apoptotic process, protein phosphorylation, cytosol, protein binding, and ATP binding. In addition, the anti-NPC effects of polyphyllin II mainly involved in the pathways related to cancer, especially in the PI3K-Akt signaling indicated by the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. The “drug-target-disease” network diagram indicated that the key genes were SRC, MAPK1, MAPK14, and AKT1. Taken together, this study revealed the potential drug targets and underlying mechanisms of polyphyllin II against NPC through modern network pharmacology, which provided a certain theoretical basis for the future nano TCM research. |
| format | Article |
| id | doaj-art-2dae1d28f00c4a0e99e629c6fd849d9e |
| institution | Kabale University |
| issn | 1565-3633 1687-479X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Bioinorganic Chemistry and Applications |
| spelling | doaj-art-2dae1d28f00c4a0e99e629c6fd849d9e2025-02-03T01:25:45ZengWileyBioinorganic Chemistry and Applications1565-36331687-479X2021-01-01202110.1155/2021/99596349959634Network Pharmacology Reveals Polyphyllin II as One Hit of Nano Chinese Medicine Monomers against Nasopharyngeal CarcinomaMeng-Zhe Yang0Bei-Bei Zhang1Jian-Chun Huang2Xian-Yu Bai3Zhen-Qiang Liang4Xiang Yi5Ning Xu6Yuan-Jiao Huang7Ai-Jun Jiao8Graduate School of Guangxi Medical University, Nanning, ChinaInstitute of Biomedical Research, Yunnan University, Kunming, ChinaPharmaceutical College, Guangxi Medical University, Nanning, ChinaGraduate School of Guangxi Medical University, Nanning, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Tumor Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Neurology, The First People’s Hospital of Nanning, Fifth Affiliated Hospital of Guangxi Medical University, Nanning, ChinaLife Science Institute, Guangxi Medical University, Nanning, ChinaPharmaceutical College, Guangxi Medical University, Nanning, ChinaNasopharyngeal carcinoma (NPC) is a malignant tumor in southern China, and nano Traditional Chinese Medicine (TCM) represents great potential to cancer therapy. To predict the potential targets and mechanism of polyphyllin II against NPC and explore its possibility for the future nano-pharmaceutics of Chinese medicine monomers, network pharmacology was included in the present study. Totally, ninety-four common potential targets for NPC and polyphyllin II were discovered. Gene Ontology (GO) function enrichment analysis showed that biological processes and functions mainly concentrated on apoptotic process, protein phosphorylation, cytosol, protein binding, and ATP binding. In addition, the anti-NPC effects of polyphyllin II mainly involved in the pathways related to cancer, especially in the PI3K-Akt signaling indicated by the Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. The “drug-target-disease” network diagram indicated that the key genes were SRC, MAPK1, MAPK14, and AKT1. Taken together, this study revealed the potential drug targets and underlying mechanisms of polyphyllin II against NPC through modern network pharmacology, which provided a certain theoretical basis for the future nano TCM research.http://dx.doi.org/10.1155/2021/9959634 |
| spellingShingle | Meng-Zhe Yang Bei-Bei Zhang Jian-Chun Huang Xian-Yu Bai Zhen-Qiang Liang Xiang Yi Ning Xu Yuan-Jiao Huang Ai-Jun Jiao Network Pharmacology Reveals Polyphyllin II as One Hit of Nano Chinese Medicine Monomers against Nasopharyngeal Carcinoma Bioinorganic Chemistry and Applications |
| title | Network Pharmacology Reveals Polyphyllin II as One Hit of Nano Chinese Medicine Monomers against Nasopharyngeal Carcinoma |
| title_full | Network Pharmacology Reveals Polyphyllin II as One Hit of Nano Chinese Medicine Monomers against Nasopharyngeal Carcinoma |
| title_fullStr | Network Pharmacology Reveals Polyphyllin II as One Hit of Nano Chinese Medicine Monomers against Nasopharyngeal Carcinoma |
| title_full_unstemmed | Network Pharmacology Reveals Polyphyllin II as One Hit of Nano Chinese Medicine Monomers against Nasopharyngeal Carcinoma |
| title_short | Network Pharmacology Reveals Polyphyllin II as One Hit of Nano Chinese Medicine Monomers against Nasopharyngeal Carcinoma |
| title_sort | network pharmacology reveals polyphyllin ii as one hit of nano chinese medicine monomers against nasopharyngeal carcinoma |
| url | http://dx.doi.org/10.1155/2021/9959634 |
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