Testing the causal impact of plasma amyloid on total Tau using a genetically informative sample of adult male twins

Testing the causal impact of plasma amyloid on total Tau using a genetically informative sample of adult male twins

The amyloid cascade hypothesis predicts that amyloid-beta (Aβ) aggregation drives tau tangle accumulation. We tested competing causal and non-causal hypotheses regarding the direction of causation between Aβ40 and Aβ42 and total Tau (t-Tau) plasma biomarkers. Plasma Aβ40, Aβ42, t-Tau, and neurofilam...

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Main Authors: Nathan A. Gillespie, Michael C. Neale, Matthew S. Panizzon, Ruth E. McKenzie, Xin M. Tu, Hong Xian, Chandra A. Reynolds, Michael J. Lyons, Robert A. Rissman, Jeremy A. Elman, Carol Franz, William S. Kremen
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Aging Brain
Subjects:
Cascade hypothesis
Plasma
Amyloid-beta
Tau
Twin
Gene
Online Access:http://www.sciencedirect.com/science/article/pii/S2589958925000052
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http://www.sciencedirect.com/science/article/pii/S2589958925000052

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