Randomised controlled trial of topical combination therapy chlorhexidine 0.2% and natamycin 5% versus topical natamycin 5% alone for fungal keratitis in East Africa: study protocol [version 1; peer review: 2 approved]

Randomised controlled trial of topical combination therapy chlorhexidine 0.2% and natamycin 5% versus topical natamycin 5% alone for fungal keratitis in East Africa: study protocol [version 1; peer review: 2 approved]

Introduction Fungal corneal infection (fungal keratitis [FK]) poses significant treatment challenges. The efficacy of current topical antifungals is inconsistent and often limited, especially in low and middle-income countries where the majority of FK cases occur. Topical natamycin 5% is the current...

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Main Authors: David Macleod, Einoti Matayan, William Makupa, Jeremy John Hoffman, Simon Arunga, Francis Orishaba, Abel Ebong, Reena Yadav, Astrid Leck, Muna Elisante, Tara Mtuy, Sandip Das Sanyam, Victor H Hu, Matthew J Burton
Format: Article
Language:English
Published: Wellcome 2025-03-01
Series:Wellcome Open Research
Subjects:
Clinical trial
fungal keratitis
chlorhexidine
natamycin
corneal ulcer
East Africa
eng
Online Access:https://wellcomeopenresearch.org/articles/10-165/v1
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https://wellcomeopenresearch.org/articles/10-165/v1

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