Immunogenicity and Safety Profile of Two Adjuvanted-PD-L1-Based Vaccine Candidates in Mice, Rats, Rabbits, and Cynomolgus Monkeys

Immunogenicity and Safety Profile of Two Adjuvanted-PD-L1-Based Vaccine Candidates in Mice, Rats, Rabbits, and Cynomolgus Monkeys

Background: The therapeutic blockade of the PD1/PD-L1 axis with monoclonal antibodies has led to a breakthrough in cancer treatment, as it plays a key role in the immune evasion of tumors. Nevertheless, treating patients with cancer with vaccines that stimulate a targeted immune response is another...

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Main Authors: Camila Canaán-Haden, Javier Sánchez-Ramírez, Rafael Martínez-Castillo, Mónica Bequet-Romero, Pedro Puente-Pérez, Isabel Gonzalez-Moya, Yunier Rodríguez-Álvarez, Marta Ayala-Ávila, Jorge Castro-Velazco, Olivia Cabanillas-Bernal, Marco A. De-León-Nava, Alexei F. Licea-Navarro, Yanelys Morera-Díaz
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Vaccines
Subjects:
PKPD-L1
cancer vaccine
immunogenicity
preclinical safety
Online Access:https://www.mdpi.com/2076-393X/13/3/296
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