Activation of SIRT1 by Hydroxysafflor Yellow A Attenuates Chronic Unpredictable Mild Stress‐Induced Microglia Activation and Iron Death in Depressed Rats

Activation of SIRT1 by Hydroxysafflor Yellow A Attenuates Chronic Unpredictable Mild Stress‐Induced Microglia Activation and Iron Death in Depressed Rats

ABSTRACT Background Hydroxysafflor yellow A (HSYA), the main active ingredient in safflower, possesses antioxidant and anti‐inflammatory activities. We confirmed in our previous study that HSYA exerts antidepressant effects, but further investigation is needed to uncover the exact mechanism. Herein,...

Full description

Saved in:
Bibliographic Details
Main Authors: Jianle He, Min He, Ping Yang, Jianhui Shangguan, Lingxia Jiang, Zhiqiang Liu
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Brain and Behavior
Subjects:
depression
ferroptosis
hippocampus
hydroxysafflor yellow A
microglia activation
Online Access:https://doi.org/10.1002/brb3.70385
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1002/brb3.70385

Similar Items