Unveiling alternative splicing dynamics in activated T lymphocytes and their implications for immune checkpoint blockade efficacy

Unveiling alternative splicing dynamics in activated T lymphocytes and their implications for immune checkpoint blockade efficacy

Summary: Alternative splicing (AS) generates diverse mRNA transcripts from a single gene, enhancing protein variety. This study examines AS during naive CD4 T cell activation, revealing that splicing events precede gene expression changes, evident as early as 6 h post-activation. Splicing alteration...

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Main Authors: Elad Zisman, Ori Stern, Reyut Lewis, Shay Tzaban, Thomas Eisenhaure, Sarah E. Henrickson, Moshe Sade-Feldman, Shira Silberman-Klein, Galit Eisenberg, Nir Hacohen, Keren Yizhak, Michal Lotem
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:iScience
Subjects:
Biological sciences
Immune response
Immunology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225006959
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http://www.sciencedirect.com/science/article/pii/S2589004225006959

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