Venetoclax confers synthetic lethality to chidamide in preclinical models with transformed follicular lymphoma

Venetoclax confers synthetic lethality to chidamide in preclinical models with transformed follicular lymphoma

Abstract Transformed follicular lymphoma (t-FL) is an aggressive and heterogeneous hematological malignancy with limited treatment success; the development of novel therapeutic approaches is urgently needed for patients with t-FL. Here, we conducted high-throughput screening (HTS) and in vitro exper...

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Main Authors: Mengya Zhong, Guangchao Pan, Jinshui Tan, Jingwei Yao, Yating Liu, Jiewen Huang, Yuelong Jiang, Depeng Zhu, Jintao Zhao, Bing Xu, Jie Zha
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Clinical Epigenetics
Subjects:
Transformed follicular lymphoma (t-FL)
High-throughput screening (HTS)
Venetoclax
Chidamide
Wnt signaling
Online Access:https://doi.org/10.1186/s13148-025-01878-0
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https://doi.org/10.1186/s13148-025-01878-0

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