Neuroinflammation and glycosylation-related cerebrospinal fluid proteins for predicting functional decline in amyotrophic lateral sclerosis: a proteomic study

Neuroinflammation and glycosylation-related cerebrospinal fluid proteins for predicting functional decline in amyotrophic lateral sclerosis: a proteomic study

BackgroundThe rate of disease progression varies widely among patients with amyotrophic lateral sclerosis (ALS). Prognostic assessment using biomarkers is highly anticipated to improve clinical trial design. We aimed to explore the cerebrospinal fluid (CSF) for prognostic biomarkers to predict futur...

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Main Authors: Kimie Nakamura, Koji Fujita, Motohisa Suzuki, Akiyoshi Kunugi, Yoshihiko Hirozane, Tomonori Kunikata, Bitoku Takahashi, Genta Narazaki, Hirofumi Kondo, Shotaro Haji, Keisuke Hirai, Yuishin Izumi
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Neurology
Subjects:
amyotrophic lateral sclerosis
biomarker
cerebrospinal fluid
glycosylation
neuroinflammation
progression rate
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2024.1418320/full
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https://www.frontiersin.org/articles/10.3389/fneur.2024.1418320/full

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