Biosilica nanoparticulate scavengers for the therapy of hepatic ischemia–reperfusion injury in preclinical models

Biosilica nanoparticulate scavengers for the therapy of hepatic ischemia–reperfusion injury in preclinical models

Abstract Hepatic ischemia–reperfusion injury (IRI), involving intracellular Ca2+ overload, oxidative stress, inflammatory network, and microcirculation disturbance, remains unsolved clinically. Here, we design a biosilica nanoparticulate scavenger PEI-arg@MON@BA for IRI therapy, via a biomimetic sil...

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Main Authors: Bingxin Zhou, Xuchun Chen, Renyu Ding, Zhongyun Bi, Tongyi Zhao, Ruilin Zhou, Miao Xu, Jiawen Li, Xinrui Jiang, Heran Li
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62968-4
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https://doi.org/10.1038/s41467-025-62968-4

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