ULBP2 CAR-T cells enhance gastric cancer immunotherapy by inhibiting CAF activation

ULBP2 CAR-T cells enhance gastric cancer immunotherapy by inhibiting CAF activation

Abstract Gastric cancer (GC) is characterised by a dense stromal microenvironment, lack of therapeutic targets, and limited effective treatment options, collectively leading to a poor prognosis. Here, we identify UL16 binding protein 2 (ULBP2) as a potential therapeutic target in GC. Mechanistically...

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Main Authors: Wentao Zhang, Wen Ren, Shuyan Guo, Haobo Han, Weiwen Cai, Haowen Bai, Long Li, Xiangyan Jiang, Xin Zheng, Tiansheng Zhang, Yan Wang, Huili Ye, Hongtai Cao, Wengui Shi, Huinian Zhou, Zeyuan Yu, Long Qin, Zuoyi Jiao
Format: Article
Language:English
Published: Nature Publishing Group 2025-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07905-5
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https://doi.org/10.1038/s41419-025-07905-5

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