Dose-dependent incidence of agranulocytosis in patients treated with methimazole and propylthiouracil

Dose-dependent incidence of agranulocytosis in patients treated with methimazole and propylthiouracil

Agranulocytosis is a serious adverse effect of methimazole (MMI) and propylthiouracil (PTU), and although there have been reports suggesting a dose-dependent incidence in relation to both drugs, the evidence has not been conclusive. The objective of our study was to determine whether the incidences...

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Main Authors: Jaeduk Yoshimura Noh, Kosuke Inoue, Nami Suzuki, Ai Yoshihara, Miho Fukushita, Masako Matsumoto, Hideyuki Imai, Shigenori Hiruma, Masahiro Ichikawa, Masakazu Koshibu, Akiko Sankoda, Rei Hirose, Natsuko Watanabe, Kiminori Sugino, Koichi Ito
Format: Article
Language:English
Published: The Japan Endocrine Society 2024-07-01
Series:Endocrine Journal
Subjects:
agranulocytosis
methimazole
propylthiouracil
dose dependency
Online Access:https://www.jstage.jst.go.jp/article/endocrj/71/7/71_EJ24-0135/_html/-char/en
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https://www.jstage.jst.go.jp/article/endocrj/71/7/71_EJ24-0135/_html/-char/en

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