A novel tetrahedral framework nucleic acid-based antibiotic delivery system: overcoming biofilm barriers to combat chronic infections

Abstract Background Overcoming bacterial biofilm barriers to enhance the efficacy of antibiotics remains a major therapeutic challenge, necessitating the development of efficient and biocompatible drug delivery systems. While framework nucleic acids (FNAs) have emerged as promising candidates for ov...

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Bibliographic Details
Main Authors: Yue Hu, Zhou Chen, Xinggang Mao, Di Qu, Dongsheng Zhai, Na Li, Shan Zhou, Xiaoyan Xue, Mingkai Li
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Nanobiotechnology
Online Access:https://doi.org/10.1186/s12951-025-03553-1
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