Novel gene rearrangement leads to altered expression of Hornerin in sensitive and chemoresistant ovarian cancer

Novel gene rearrangement leads to altered expression of Hornerin in sensitive and chemoresistant ovarian cancer

Background: Hornerin (HRNR) is part of the S100-fused protein family and has been linked to poorer prognosis in various cancers, though the mechanisms remain unclear. This study aimed to explore the role of HRNR in ovarian cancer. Methods: We conducted proteomic analysis (n = 252) and RNA sequencing...

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Main Authors: Ghassan M. Saed, Harvey Sharma, Jenna Dabaja, Asad Nawaz, Ayesha Alvero, Robert T. Morris, Asma Basha, Lucas Werner, Toshima Z. Parris, Khalil Helou
Format: Article
Language:English
Published: Elsevier 2025-11-01
Series:Translational Oncology
Subjects:
Gene rearrangement
Hornerin expression
Chemoresistance
Ovarian cancer
Therapeutic marker
Hornerin mutations
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523325002268
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http://www.sciencedirect.com/science/article/pii/S1936523325002268

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