Differential Effects of Biomimetic Thymine Dimers and Corresponding Photo-Adducts in Primary Human Keratinocytes and Fibroblasts

Differential Effects of Biomimetic Thymine Dimers and Corresponding Photo-Adducts in Primary Human Keratinocytes and Fibroblasts

UVB radiation induces DNA damage generating several thymine photo-adducts (TDPs), which can lead to mutations and cellular transformation. The DNA repair pathways preserve genomic stability by recognizing and removing photodamage. These DNA repair side products may affect cellular processes. We prev...

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Bibliographic Details
Main Authors: Rosanna Monetta, Denise Campagna, Valeria Bartolocci, Alessio Capone, Massimo Teson, Silvia Filippi, Sofia Gabellone, Davide Piccinino, Raffaele Saladino, Elena Dellambra
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomolecules
Subjects:
thymine dimers
keratinocytes
fibroblasts
skin
UVB radiation
Online Access:https://www.mdpi.com/2218-273X/14/12/1484
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