Mitigating T-cell mitochondrial dysfunction in CLL to augment CAR T-cell therapy: evaluation in an immunocompetent model

Mitigating T-cell mitochondrial dysfunction in CLL to augment CAR T-cell therapy: evaluation in an immunocompetent model

Abstract: An unmet clinical need in chronic lymphocytic leukemia (CLL) is emerging due to the rapidly expanding group of patients with double refractory (Bruton's tyrosine kinase- and B-cell lymphoma 2-inhibitor) disease. So far, autologous T-cell–based therapies, including chimeric antigen rec...

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Main Authors: Wael Gamal, Nienke B. Goedhart, Helga Simon-Molas, Melanie Mediavilla-Varela, Angimar Uriepero-Palma, Fleur S. Peters, Kamira Maharaj, Julio C. Chavez, John Powers, Alyssa Obermayer, Timothy I. Shaw, José R. Conejo-Garcia, Paulo C. Rodriguez, Eva Sahakian, Javier Pinilla-Ibarz, Arnon P. Kater
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952925000990
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