DNA G-quadruplex structures act as functional elements in α- and β-globin enhancers

DNA G-quadruplex structures act as functional elements in α- and β-globin enhancers

Abstract Background Enhancer elements interact with target genes at a distance to modulate their expression, but the molecular details of enhancer–promoter interaction are incompletely understood. G-quadruplex DNA secondary structures (G4s) have recently been shown to co-occur with 3D chromatin inte...

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Bibliographic Details
Main Authors: Colm Doyle, Krzysztof Herka, Sean M. Flynn, Larry Melidis, Somdutta Dhir, Stefan Schoenfelder, David Tannahill, Shankar Balasubramanian
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Genome Biology
Subjects:
Enhancers
G-quadruplex structures
3D chromatin interactions
Epigenetics
Online Access:https://doi.org/10.1186/s13059-025-03627-1
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https://doi.org/10.1186/s13059-025-03627-1

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