Factors influencing the timing of second-line therapy for the treatment of advanced hepatocellular carcinoma: a systematic review and meta-analysis

Abstract Purpose The first line palliative treatment medicine contributes modest survival benefit to advanced hepatocellular carcinoma (HCC) patients, but often fails over time. However, the appropriate timing of the second-line therapy initiation remains controversial. This meta-analysis determined...

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Bibliographic Details
Main Authors: Xiaoze Zhang, Fangyuan Zhu, Junsong Wen, Ziwei Pan, Yaodong Zhu
Format: Article
Language:English
Published: Springer 2025-06-01
Series:Holistic Integrative Oncology
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Online Access:https://doi.org/10.1007/s44178-025-00179-z
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