Protocol for the upgraded high-throughput SPME system for biocompatible in vitro extraction from small volume for metabolomics and pharmaceutical assays

Protocol for the upgraded high-throughput SPME system for biocompatible in vitro extraction from small volume for metabolomics and pharmaceutical assays

This study presents an updated application of Solid Phase Microextraction (SPME) technology for high-throughput, time-course metabolomic analysis in in vitro cell culture models. SPME, a versatile and minimally invasive sample preparation technique, was integrated with 96-well plate systems to enhan...

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Bibliographic Details
Main Authors: Paulina Szeliska, Karol Jaroch, Bartłomiej Charemski, Kübra Kahremanoğlu, Enes Çetin, Ezel Boyaci, Barbara Bojko
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Green Analytical Chemistry
Subjects:
Solid phase microextraction
LC-MS
Cell cultures in vitro
High-throughput sample preparation
Metabolomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2772577425000345
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http://www.sciencedirect.com/science/article/pii/S2772577425000345

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