Verification of emerging genomic mutations in Mycobacterium tuberculosis allows transmission chains to be distinguished in an epidemiological typing cluster extending over thirty years.

Verification of emerging genomic mutations in Mycobacterium tuberculosis allows transmission chains to be distinguished in an epidemiological typing cluster extending over thirty years.

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Whole genome sequencing (WGS) is able to identify epidemiological links between Mycobacterium tuberculosis isolates. Recent clustering can be ruled out using a pre-defined single nucleotide polymorphism (SNP) threshold. If WGS clusters grow significantly over time limited genetic variability hampers...

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Main Authors: Rina de Zwaan, Gerard de Vries, Ella Ubbelohde, Arnout Mulder, Miranda Kamst-van Agterveld, Karin Rebel, Saskia Kautz, Kristin Kremer, Richard M Anthony, Dick van Soolingen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0319630
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https://doi.org/10.1371/journal.pone.0319630

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