Endogenous protein S100A14 stabilizes glutaminase to render hepatocellular carcinoma resistant to sorafenib

Endogenous protein S100A14 stabilizes glutaminase to render hepatocellular carcinoma resistant to sorafenib

Abstract Background Many cases of advanced hepatocellular carcinoma (HCC) are resistant to the widely used drug sorafenib, which worsens prognosis. While many studies have explored how acquired resistance emerges during drug exposure, the mechanism underlying primary resistance before treatment stil...

Full description

Saved in:
Bibliographic Details
Main Authors: Menghui Wang, Yueheng Li, Junhui Su, Xinjue Dong, Ao Liu, Yuqi Yang, Xinyi Tang, Ruijie Chen, QingQuan Li, Hongshan Wang, Hong Xiao
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Translational Medicine
Subjects:
Lineage tracing
Hepatocellular carcinoma
Sorafenib
Primary resistance
S100A14
Glutaminase
Online Access:https://doi.org/10.1186/s12967-025-06333-5
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12967-025-06333-5

Similar Items