Detection of CADM1, MAL, and PAX1 Methylation by ddPCR for Triage of HPV-Positive Cervical Lesions

Detection of CADM1, MAL, and PAX1 Methylation by ddPCR for Triage of HPV-Positive Cervical Lesions

The aberrant DNA methylation of tumour suppressor genes, including <i>CADM1</i>, <i>MAL</i>, and <i>PAX1</i>, is implicated in cervical carcinogenesis. <b>Objectives:</b> This pilot study aimed to evaluate the methylation levels of these genes in HPV-p...

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Bibliographic Details
Main Authors: Maria Anisimova, Mark Jain, Liya Shcherbakova, Liana Aminova, Andrey Bugerenko, Natalia Novitskaya, Larisa Samokhodskaya, Vladislav Kokarev, Victoria Inokenteva, Olga Panina
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Biomedicines
Subjects:
<i>CADM1</i>
cervical cancer
cervical intraepithelial neoplasia
DNA methylation
digital PCR
epigenetics
Online Access:https://www.mdpi.com/2227-9059/13/6/1450
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