Riociguat prevents hyperoxia-induced lung injury and pulmonary hypertension in neonatal rats without effects on long bone growth.

Riociguat prevents hyperoxia-induced lung injury and pulmonary hypertension in neonatal rats without effects on long bone growth.

Bronchopulmonary dysplasia (BPD) remains the most common and serious chronic lung disease of premature infants. Severe BPD complicated with pulmonary hypertension (PH) increases the mortality of these infants. Riociguat is an allosteric soluble guanylate cyclase stimulator and is approved by the FDA...

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Main Authors: Keyur Donda, Ronald Zambrano, Younghye Moon, Justin Percival, Ruben Vaidya, Fredrick Dapaah-Siakwan, Shihua Luo, Matthew R Duncan, Yong Bao, Luqing Wang, Ling Qin, Merline Benny, Karen Young, Shu Wu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0199927&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0199927&type=printable

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