Influence of OCT2 gene variants on metformin efficacy in type 2 diabetes: insights into pharmacogenomics and drug interactions

Influence of OCT2 gene variants on metformin efficacy in type 2 diabetes: insights into pharmacogenomics and drug interactions

Abstract Metformin, a widely prescribed treatment for type 2 diabetes mellitus (T2DM), demonstrates significant inter-individual variability in its therapeutic response. This variability is potentially driven by genetic differences in drug transporters. Among these transporters, the organic cation t...

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Main Authors: Ma’mon M. Hatmal, Omar Abuyaman, Mohammad A. I. Al-Hatamleh, Heba Tayyem, Amin N. Olaimat, Ali Mussa, Iman Aolymat, Aymen Abuawad, Mohanad Odeh, Rana Qawaqzeh
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
T2DM
Insulin
Organic cation transporters
SNP
SLC22A2
808G > T
Online Access:https://doi.org/10.1186/s12967-025-06720-y
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https://doi.org/10.1186/s12967-025-06720-y

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