Cytotoxic effects of the cigarette smoke extract of heated tobacco products on human oral squamous cell carcinoma: the role of reactive oxygen species and CaMKK2

Cytotoxic effects of the cigarette smoke extract of heated tobacco products on human oral squamous cell carcinoma: the role of reactive oxygen species and CaMKK2

Abstract Background The increasing prevalence of heated tobacco products (HTPs) has heightened concerns regarding their potential health risks. Previous studies have demonstrated the toxicity of cigarette smoke extract (CSE) from traditional tobacco’s mainstream smoke, even after the removal of nico...

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Main Authors: Nagao Kagemichi, Masanari Umemura, Soichiro Ishikawa, Yu Iida, Shota Takayasu, Akane Nagasako, Rina Nakakaji, Taisuke Akimoto, Makoto Ohtake, Takahiro Horinouchi, Tetsuya Yamamoto, Yoshihiro Ishikawa
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Journal of Physiological Sciences
Subjects:
Heated tobacco products (HTPs)
Calcium
Oral cancer
Calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2)
Reactive oxygen species (ROS)
Online Access:https://doi.org/10.1186/s12576-024-00928-1
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https://doi.org/10.1186/s12576-024-00928-1

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