Clonal expansion dictates the efficacy of mitochondrial lineage tracing in single cells

Clonal expansion dictates the efficacy of mitochondrial lineage tracing in single cells

Abstract Background Mitochondrial DNA (mtDNA) variants hold promise as endogenous barcodes for tracking human cell lineages, but their efficacy as reliable lineage markers are hindered by the complex dynamics of mtDNA in somatic tissues. Results Here, we use computational modeling and single-cell ge...

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Bibliographic Details
Main Authors: Xin Wang, Kun Wang, Weixing Zhang, Zhongjie Tang, Hao Zhang, Yuying Cheng, Da Zhou, Chao Zhang, Wen-Zhao Zhong, Qing Ma, Jin Xu, Zheng Hu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Genome Biology
Subjects:
Lineage tracing
mtDNA variants
Clonal dynamics
Single-cell genomics
Online Access:https://doi.org/10.1186/s13059-025-03540-7
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https://doi.org/10.1186/s13059-025-03540-7

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