Design, synthesis, and anti-urease evaluations of new sulfonamide-1,2,3-triazole-acetamide derivatives

Design, synthesis, and anti-urease evaluations of new sulfonamide-1,2,3-triazole-acetamide derivatives

Abstract The present study demonstrated the design and synthesis of sulfonamide-1,2,3-triazole-acetamide derivatives 11a-o and screening against urease in vitro and in silico. These compounds were designed based on reported potent urease inhibitors and optimized structurally based on substituents on...

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Main Authors: Shohreh Bakhshi Varzaneh, Amir Shervin Shokouhi Asl, Mohammad Hosein Sayahi, Amir Mohammad Taherkhani, Meysam Talebi, Navid Dastyafteh, Sajedeh Safapoor, Mehdi Emadi, Majid Alikhani, Rozita Yazzaf, Mohammad Halimi, Massoud Amanlou, Bagher Larijani, Maryam Mohammadi-Khanaposhtani, Mohammad Mahdavi
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Sulfonamide
1,2,3-Triazole-acetamide
Urease inhibitors
Online Access:https://doi.org/10.1038/s41598-025-07553-x
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https://doi.org/10.1038/s41598-025-07553-x

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