Identification of Rhododendron mariae extraction as a new attachment inhibitor against dengue virus by targeting the envelope protein domain III

Identification of Rhododendron mariae extraction as a new attachment inhibitor against dengue virus by targeting the envelope protein domain III

IntroductionDengue virus (DENV), a mosquito-borne flavivirus, leads to over 390 million annual infections worldwide, and there are no approved antivirals so far. Rhododendron mariae (RM), a traditional Chinese herb abundant in flavonoids and triterpenoids, is used to treat respiratory disorders, yet...

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Main Authors: Chunyang Tian, Yuanru Zheng, Dongkai Tang, Haiyan Tian, Lingzhu Shi, Xuemei He, Jianhai Yu, Lijun Yan, Huihui Cao, Wei Zhao, Junshan Liu, Linzhong Yu, Zibin Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
Rhododendron mariae extraction
dengue virus
antiviral
viral attachment
envelope protein domain III
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1663878/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1663878/full

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