The longitudinal association between multiple cardiometabolic diseases, socioeconomic status, and depressive symptoms in China
Abstract The aim of this study is to investigate the effect of cardiometabolic diseases (CMDs) on the development of depressive symptoms and to determine whether socioeconomic status (SES) moderates this effect. A total of 6,455 individual free from depressive symptoms were selected from the China H...
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Nature Portfolio
2025-01-01
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| author | Dan Guo Yanshang Wang Yanan Zhao Ruoxi Ding Yanan Luo Wanwei Dai Ping He |
| author_facet | Dan Guo Yanshang Wang Yanan Zhao Ruoxi Ding Yanan Luo Wanwei Dai Ping He |
| author_sort | Dan Guo |
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| description | Abstract The aim of this study is to investigate the effect of cardiometabolic diseases (CMDs) on the development of depressive symptoms and to determine whether socioeconomic status (SES) moderates this effect. A total of 6,455 individual free from depressive symptoms were selected from the China Health and Retirement Longitudinal Study (CHARLS). CMDs and SES were self-reported. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (CESD-10). Cox proportional hazards regression models were employed to examine the association between baseline CMDs and subsequent depressive symptoms. Stratified analysis were conducted to explore the moderating effect of SES on this association.Participants with any CMDs exhibited a higher risk of developing depressive symptoms compared to those without CMDs, with a hazard ratio (HR) of 1.10 (95% CI: 1.01, 1.20). Individuals with one CMD (HR = 1.08, 95% CI: 1.00, 1.20) or cardiometabolic multimorbidity (HR = 1.13, 95% CI: 1.02, 1.26) also demonstrated an increased risk. The effect of CMDs on depressive symptoms was observed primarily in adults aged 60 years and older with lower education attainment (HR = 1.28, 95%CI: 1.12, 1.46), lower income (HR = 1.29, 95%CI: 1.11, 1.50) and rural residency (HR = 1.29, 95%CI: 1.12,1.51). These findings emphasize the importance of closely monitoring the mental status of patients with CMDs and considering routine screening and evaluation for depressive symptoms, especially in individuals with low SES. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
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| spelling | doaj-art-2bfac0f3211f4a548ea9b0bb9ed546752025-01-26T12:24:38ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-025-87516-4The longitudinal association between multiple cardiometabolic diseases, socioeconomic status, and depressive symptoms in ChinaDan Guo0Yanshang Wang1Yanan Zhao2Ruoxi Ding3Yanan Luo4Wanwei Dai5Ping He6Department of Scientific Research and Teaching, China Aerospace Science & Industry Corporation 731 HospitalSchool of Public Health, Peking UniversityFaculty of Health and Wellness, City University of MacauPeking University Sixth Hospital, Peking University Institute of Mental Health, National Health Commission Key Laboratory of Mental Health (Peking University, National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)Department of Global Health, School of Public Health, Peking UniversityPeking University the Third HospitalCenter for Health Development Studies, Peking UniversityAbstract The aim of this study is to investigate the effect of cardiometabolic diseases (CMDs) on the development of depressive symptoms and to determine whether socioeconomic status (SES) moderates this effect. A total of 6,455 individual free from depressive symptoms were selected from the China Health and Retirement Longitudinal Study (CHARLS). CMDs and SES were self-reported. Depressive symptoms were assessed using the Center for Epidemiologic Studies Depression Scale (CESD-10). Cox proportional hazards regression models were employed to examine the association between baseline CMDs and subsequent depressive symptoms. Stratified analysis were conducted to explore the moderating effect of SES on this association.Participants with any CMDs exhibited a higher risk of developing depressive symptoms compared to those without CMDs, with a hazard ratio (HR) of 1.10 (95% CI: 1.01, 1.20). Individuals with one CMD (HR = 1.08, 95% CI: 1.00, 1.20) or cardiometabolic multimorbidity (HR = 1.13, 95% CI: 1.02, 1.26) also demonstrated an increased risk. The effect of CMDs on depressive symptoms was observed primarily in adults aged 60 years and older with lower education attainment (HR = 1.28, 95%CI: 1.12, 1.46), lower income (HR = 1.29, 95%CI: 1.11, 1.50) and rural residency (HR = 1.29, 95%CI: 1.12,1.51). These findings emphasize the importance of closely monitoring the mental status of patients with CMDs and considering routine screening and evaluation for depressive symptoms, especially in individuals with low SES.https://doi.org/10.1038/s41598-025-87516-4Cardiometabolic diseasesCardiometabolic multimorbidityDepressive symptomsSocioeconomic statusMiddle-aged and older adults |
| spellingShingle | Dan Guo Yanshang Wang Yanan Zhao Ruoxi Ding Yanan Luo Wanwei Dai Ping He The longitudinal association between multiple cardiometabolic diseases, socioeconomic status, and depressive symptoms in China Scientific Reports Cardiometabolic diseases Cardiometabolic multimorbidity Depressive symptoms Socioeconomic status Middle-aged and older adults |
| title | The longitudinal association between multiple cardiometabolic diseases, socioeconomic status, and depressive symptoms in China |
| title_full | The longitudinal association between multiple cardiometabolic diseases, socioeconomic status, and depressive symptoms in China |
| title_fullStr | The longitudinal association between multiple cardiometabolic diseases, socioeconomic status, and depressive symptoms in China |
| title_full_unstemmed | The longitudinal association between multiple cardiometabolic diseases, socioeconomic status, and depressive symptoms in China |
| title_short | The longitudinal association between multiple cardiometabolic diseases, socioeconomic status, and depressive symptoms in China |
| title_sort | longitudinal association between multiple cardiometabolic diseases socioeconomic status and depressive symptoms in china |
| topic | Cardiometabolic diseases Cardiometabolic multimorbidity Depressive symptoms Socioeconomic status Middle-aged and older adults |
| url | https://doi.org/10.1038/s41598-025-87516-4 |
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