GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis

GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis

Abstract Background Cardiac fibrosis following myocardial infarction (MI) drives adverse ventricular remodeling and heart failure, with cardiac fibroblasts (CFs) playing a central role. GSTM1 is an important member of the glutathione S-transferase (GSTs) family, which plays an important role in main...

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Main Authors: Kai-Jie Chen, Yue Zhang, Xin-Yi Zhu, Shuo Yu, Yao Xie, Cheng-Jiang Jin, Yi-Min Shen, Si-Yu Zhou, Xiao-Ce Dai, Sheng-An Su, Lan Xie, Zheng-Xing Huang, Hui Gong, Mei-Xiang Xiang, Hong Ma
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Military Medical Research
Subjects:
GSTM1
Ferroptosis
Cardiac fibrosis
Myocardial infarction (MI)
Lipid peroxidation
Glutathione peroxidase 4
Online Access:https://doi.org/10.1186/s40779-025-00610-6
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https://doi.org/10.1186/s40779-025-00610-6

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