The interplay between COX-2, chemotherapeutic drugs, and chemoresistance in colon cancer

The interplay between COX-2, chemotherapeutic drugs, and chemoresistance in colon cancer

Abstract Chemoresistance and tumor relapse remain major clinical problems. Evidence indicates that COX2/PGE2/EP axis has a critical role in tumorogenesis and chemoresistance. This study assessed the relation of the COX-2 gene expression with chemoresistance in colon cancer (CC) patients. Also, it ex...

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Bibliographic Details
Main Authors: Sally M. Shalaby, Salma A. Shawky, Hassan Ashour, Walaa Sarhan
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Colon cancer
COX-2
Chemoresistance
Chemotherapy
Online Access:https://doi.org/10.1038/s41598-025-98451-9
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https://doi.org/10.1038/s41598-025-98451-9

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