Preparation and property evaluation of oral colon targeted protein delivery system with sodium alginate and chitosan
Abstract Oral administration of protein-based biologics faces challenges such as low bioavailability and a short half-life in the gastrointestinal tract. This study focuses on developing a novel encapsulation technique using sodium alginate and chitosan to create nanospheres that efficiently deliver...
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| Main Authors: | Long Ma, Wentao Zhou, Xizhi Ma, Xiaopo Li, Qian Zhang, Wenting Ma, Nafei Chen, XiaoTao Zhou, XiaoHui Tang |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-07-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-04983-5 |
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