Preparation and property evaluation of oral colon targeted protein delivery system with sodium alginate and chitosan

Preparation and property evaluation of oral colon targeted protein delivery system with sodium alginate and chitosan

Abstract Oral administration of protein-based biologics faces challenges such as low bioavailability and a short half-life in the gastrointestinal tract. This study focuses on developing a novel encapsulation technique using sodium alginate and chitosan to create nanospheres that efficiently deliver...

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Bibliographic Details
Main Authors: Long Ma, Wentao Zhou, Xizhi Ma, Xiaopo Li, Qian Zhang, Wenting Ma, Nafei Chen, XiaoTao Zhou, XiaoHui Tang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Single-factor experiment
Response surface experiments
SA-BSA-CS
Protein-based biologics
Biosafety
Online Access:https://doi.org/10.1038/s41598-025-04983-5
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https://doi.org/10.1038/s41598-025-04983-5

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