Analgesic effect of a bradykinin antagonist – a 1,4-benzodiazepine-2-one derivative

Analgesic effect of a bradykinin antagonist – a 1,4-benzodiazepine-2-one derivative

Aim. To study the analgesic effect of a new 1,4-benzodiazepine-2-one derivative (codenamed PAV-0056) in pain models in mice, its anti-inflammatory effect in experimental exudative inflammation in rats, and its potential ulcerogenic effect.Materials and methods. A 1,4-benzodiazepine-2-one derivative...

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Bibliographic Details
Main Authors: A. E. Aliforenko, V. V. Bykov, A. V. Bykova, V. S. Motov, S. A. Stankevich, V. I. Pavlovsky, V. A. Khazanov, A. I. Vengerovskii
Format: Article
Language:English
Published: Siberian State Medical University (Tomsk) 2023-07-01
Series:Бюллетень сибирской медицины
Subjects:
1,4-benzodiazepine-2-one derivative
analgesic
anti-inflammatory
and potential ulcerogenic effects
mice
rats
Online Access:https://bulletin.ssmu.ru/jour/article/view/5213
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