Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice

Heterozygosity for neurodevelopmental disorder-associated TRIO variants yields distinct deficits in behavior, neuronal development, and synaptic transmission in mice

Genetic variants in TRIO are associated with neurodevelopmental disorders (NDDs) including schizophrenia (SCZ), autism spectrum disorder (ASD), and intellectual disability. TRIO uses its two guanine nucleotide exchange factor (GEF) domains to activate GTPases (GEF1: Rac1 and RhoG; GEF2: RhoA) that c...

Full description

Saved in:
Bibliographic Details
Main Authors: Yevheniia Ishchenko, Amanda T Jeng, Shufang Feng, Timothy Nottoli, Cindy Manriquez-Rodriguez, Khanh K Nguyen, Melissa G Carrizales, Matthew J Vitarelli, Ellen E Corcoran, Charles A Greer, Samuel A Myers, Anthony J Koleske
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-06-01
Series:eLife
Subjects:
TRIO
Neurodevelopmental disorders
Rac1
presynaptic
RhoA
Online Access:https://elifesciences.org/articles/103620
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://elifesciences.org/articles/103620

Similar Items