Structural convergence and membrane interactions of Aβ1-42 along the primary nucleation process studied by solid state NMR

Structural convergence and membrane interactions of Aβ1-42 along the primary nucleation process studied by solid state NMR

Abstract Non-specific disruption of cellular membranes induced by amyloidogenic aggregation of β-amyloid (Aβ) peptides remains a viable cytotoxicity mechanism in Alzheimer’s disease (AD). Obtaining structural information about the intermediate states of Aβ-membrane systems and their molecular intera...

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Main Authors: Maurine K. Kengwerere, June M. Kenyaga, Peng Xiao, Shubha S. Gunaga, Faith J. Scott, Xyomara Wutoh-Hughes, James Wang, Brian Lum, Yan Sun, Frederic Mentink-Vigier, Tuo Wang, Wei Qiang
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01537-8
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https://doi.org/10.1038/s42004-025-01537-8

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