Synthesis and evaluation of carmofur analogs as antiproliferative agents, inhibitors to the main protease (Mpro) of SARS-CoV-2, and membrane rupture-inducing agents

Synthesis and evaluation of carmofur analogs as antiproliferative agents, inhibitors to the main protease (Mpro) of SARS-CoV-2, and membrane rupture-inducing agents

Abstract Initially developed as a derivatized analog of 5-fluorouracil for the treatment of colorectal cancer, carmofur has more recently demonstrated potent covalent inhibition of the main protease (Mpro) of SARS-CoV-2. Harnessing our previously described workflow for the optimized preparation of c...

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Bibliographic Details
Main Authors: Tiffany Gu, Amber Lu, Xina Wang, Natalie Brahan, Lexi Xu, Leyuan Zhang, Kaitlyn Su, Kody Seow, Julia Vu, Charissa Luk, Yunseo Lee, Anirudh Raman, Joseph Pazzi, Edward Njoo
Format: Article
Language:English
Published: Springer 2025-04-01
Series:Discover Chemistry
Subjects:
Carmofur
Mpro
Acid ceramidase
Giant unilamellar vesicles
5-FU
Antimetabolites
Online Access:https://doi.org/10.1007/s44371-025-00144-9
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https://doi.org/10.1007/s44371-025-00144-9

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