A glutathione-responsive ferroptotic inducer with elevated labile iron pool and self-supplied peroxide for chemodynamic therapy

A glutathione-responsive ferroptotic inducer with elevated labile iron pool and self-supplied peroxide for chemodynamic therapy

Chemodynamic therapy (CDT) is a novel approach in the treatment of tumors in which ferrous iron (Fe2+) is the primary catalyst of the Fenton reaction. However, Fe2+ is typically stored in an oxidized mineral form as ferric iron (Fe3+) in ferritin, significantly limiting the efficacy of CDT. This wor...

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Bibliographic Details
Main Authors: Penghui Wei, Xuegang Niu, Dengliang Wang, Chengzhong Du, Mingtao Zhu, Hongjia Zheng, Yongrui Hu, Yu Tian, Wei Huang, Chengyu Ding, Yuanxiang Lin, Yang Zhu, Dezhi Kang
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Materials Today Bio
Subjects:
Chemodynamic therapy
Ferritin heavy chain
Labile iron pool
O-GlcNAcylation
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425004831
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