A phase I study of S-1 and cisplatin with concurrent hypofractionated carbon-ion radiotherapy for patients with stage III non-small cell lung cancer

A phase I study of S-1 and cisplatin with concurrent hypofractionated carbon-ion radiotherapy for patients with stage III non-small cell lung cancer

ObjectivesWe conducted a phase I study to evaluate the recommended dose of S-1 in combination with cisplatin (SP) and concurrent carbon ion radiotherapy (CIRT) in patients with stage III locally advanced non-small cell lung cancer (LA-NSCLC).Materials and methodsS-1 was administered orally twice dai...

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Bibliographic Details
Main Authors: Yosuke Miura, Nobuteru Kubo, Noriaki Sunaga, Naoko Okano, Hiroaki Tsurumaki, Hidemasa Kawamura, Reiko Sakurai, Toshitaka Maeno, Takeshi Hisada, Tatsuya Ohno
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Oncology
Subjects:
carbon-ion radiotherapy
concurrent chemoradiotherapy
non-small cell lung cancer
platinum-based chemotherapy
clinical trial
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1573462/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1573462/full

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