Development of novel pyrimidine-thio-triazoles targeting EGFR in breast Cancer cells via one-pot copper-catalyzed 1,3-dipolar cycloaddition

Development of novel pyrimidine-thio-triazoles targeting EGFR in breast Cancer cells via one-pot copper-catalyzed 1,3-dipolar cycloaddition

Background: Heterocycles are vital in medicinal chemistry due to their diverse pharmacological activities against various diseases. The development of innovative synthetic methods for heterocycles is ongoing, aiming to explore their full therapeutic potential. The epidermal growth factor receptor (E...

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Main Authors: Bhanuprakash C. Narasimhachar, Akshay Ravish, Narasimha M. Beeraka, Baburajeev Chumadathil Pookunoth, Shreeja Basappa, Divakar Vishwanath, Kanchugarakoppal S. Rangappa, Omantheswara Nagaraja, Mahendra Madegowda, Paduvalahippe Gowdegowda Chandrashekara, Basappa Basappa
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Results in Chemistry
Subjects:
Arylamine
Triazole
Pyrimidine
Piperazine
Benzimidazole
Online Access:http://www.sciencedirect.com/science/article/pii/S221171562500133X
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