Substitution of Proline Residues by 4-Fluoro-<span style="font-variant: small-caps">l</span>-Proline Affects the Mechanism of the Proline-Rich Antimicrobial Peptide Api137

Substitution of Proline Residues by 4-Fluoro-<span style="font-variant: small-caps">l</span>-Proline Affects the Mechanism of the Proline-Rich Antimicrobial Peptide Api137

<b>Background</b>: The well-studied 18-residue-long proline-rich antimicrobial designer peptide Api137 utilizes at least two lethal intracellular mechanisms that target the bacterial 70S ribosome. First, Api137 stalls the ribosome by binding to the peptidyl-transferase center, trapping t...

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Bibliographic Details
Main Authors: Maren Reepmeyer, Andor Krizsan, Alexandra Brakel, Lisa Kolano, Jakob Gasse, Benjamin W. Husselbee, Andrea J. Robinson, Ralf Hoffmann
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Antibiotics
Subjects:
PrAMP
Api137
Fluoro-<span style="font-variant: small-caps">l</span>-proline
mode of action
Online Access:https://www.mdpi.com/2079-6382/14/6/566
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