Single-cell transcriptomic analysis reveals prognosis-related stromal signatures that potentiate stratification of patients with extrahepatic cholangiocarcinoma

Single-cell transcriptomic analysis reveals prognosis-related stromal signatures that potentiate stratification of patients with extrahepatic cholangiocarcinoma

Abstract Background Extrahepatic cholangiocarcinoma (eCCA) is a rare but refractory cancer with dense desmoplasia. Prognosis-associated stromal cells in eCCA remain poorly characterized. Here, we profiled the tumor cellular composition and identified prognosis-related stromal signatures by single-ce...

Full description

Saved in:
Bibliographic Details
Main Authors: Chen Ni, Rulin Hua, Yuanyuan Yang, Jialu Liang, Wentao Liu, Linlin Wang, Xiaohan Yao, Anqi Li, Long Yu, Ruo Feng, Dekang Lv, Zhihai Qin, Wenlong Zhai
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Gastroenterology
Subjects:
Extrahepatic cholangiocarcinoma
Single-cell RNA sequencing
Tumor stroma
Molecular classification
Patient stratification
Prognosis
Online Access:https://doi.org/10.1186/s12876-025-03829-8
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s12876-025-03829-8

Similar Items